Ozone is a very reactive gas and is toxic for the respiratory system but, under precise rules, it can be therapeutically useful for human disease with a chronic oxidative stress. Ozone is an extremely versatile drug and the therapeutic range has been precisely defined to exclude acute and chronic toxicity. It is remarkable that the majority of patients report a feeling of wellness using prolonged ozone therapy. Particularly in chronic skin infections and ulcers, which affect millions of patients, the use of parenteral and topical ozone applications is far more effective than conventional medications for enhancing healing, simply because ozone disinfects, oxygenates and stimulates cell proliferation. The critical point remains an exhaustive clinical evaluation of ozone therapy in the outlined diseases. Orthodox medicine remains skeptical because multi-center and extensive clinical trials are not yet available owing to the lack of sponsors. An unfavorable combination of factors such as a wrong dogma, the fact that ozone is one of the worst troposphere pollutants and past misuse of ozone have led to a poor consideration of ozone therapy. However, basic and clinical work, developed during the last two decades, clarified both the biochemical and molecular mechanisms of action of ozone in biology and medicine. A judicious dose of ozone dissolved in blood immediately triggers a cascade of well defined chemical compounds acting on multiple cellular targets according to well-known biochemical and molecular pathways. Ozone therapy is proving to be very useful in the dry form of age-related macular degeneration (AMD), cardiovascular diseases, chronic obstructive pulmonary disease (COPD), cerebral diseases and healing disorders, where conventional medicine appears insufficient and too expensive. It is time that World Health Authorities abandon prejudice and skepticism and start to take advantage of an integrative medical application able to help the majority of world population. Among complementary medical approaches, ozone therapy is known all over the world but it is not yet practiced correctly everywhere because of the incomplete knowledge by improvised ozone therapists. However, on the basis of basic and small clinical studies performed in the last two decades, it has become clear that ozone, in very small dosages, behaves as a real drug and the biochemical and molecular mechanism of action are well within orthodox medicine. Ethical Committees are sometimes reluctant to give permission for clinical trials because they prefer pharmaceuticals able to pay huge sums for insurance and all clinical tests. The few and small National Associations of ozone therapy, in comparison to the Pharmaceutical Industries, which register an annual business of many billion dollars, have no financial power and are unable to support expensive clinical studies.
Dr. Emma Borrelli
Department of Medical Biotechnologies, University of Siena, Italy.
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