The Morphological Basis and Laws of Autopsy Interpretation: Exploring the Relationship between the Basic Medical Sciences, Anatomical Pathology and Clinical Practice | Chapter 08 | Current Trends in Medicine and Medical Research Vol. 4

The  discipline  of  Morbid  Anatomy  or  Anatomical  Pathology  is  a  bridge  between  the  basic  medical sciences  and  the  clinical  sciences [1]. It  is  clinico-pathologic  discipline  which  deals  with  the identification  of  lesions,  interpreting  them  correctly  at  the  macroscopic  and  microscopic  levels  and relating them appropriately to known diseases within the context of the index patient[2].Lesions are the structural alterations seen in tissues as a result of the assault of the injurious agent or pathological process. Thus, anatomical pathology establishes the basis for the ‘dis ease’ or discomfort in patients. The human cell is known to be the most basic unit of life and the tissue is constituted by cells having related functions. Injurious agents affect cell structure and ultimately the physiology and therefore the cell is the natural habitat of the disease processes. Histopathology seeks to interpret the changes in the cell to define the aetiology, evolution and progression of disease.  An afflicted cell continues to perform  its  functions  at  various  degrees  of  capability  as  it  finds  itself  able  to  adapt  to  negative situations  and  maintain  homeostasis.  Each cell’s preserved structure guarantees preserved biochemical constitution and therefore its routine physiological functions. A compromise in structure without resolution or failure of homeostasis automatically leads to poor biochemistry of the cells and poor functioning. Tissues with related or complementary functions constitute organs and organs with related  functions  and  contributory  physiological  relationships  constitute  organ  systems  which essentially  make up the whole human being. The relationship between anatomy, biochemistry and physiology is interminable and inseparable though disease causing agents violate this union.

Author(s) Details

Akinwumi O. Komolafe

Department of Morbid Anatomy and Forensic Medicine, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria and Department of Morbid Anatomy and  Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State, Nigeria.

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