TNF-α Inhibitor Treatment for Crohn’s Disease: Comparative Review of Post Therapy Malignancy between Infliximab and Adalimumab | Chapter 08 | Modern Advances in Pharmaceutical Research Vol. 2

The association between chronic inflammatory disease and cancer has been well established through years of research. In corollary, progressive resistance to chimeric monoclonal antibodies has been reported in literature. The purpose of this investigation was to establish the overall trend of the chimeric monoclonal antibody (Infliximab) failure compared with human monoclonal antibody (Adalimumab). It was opined that this failure may result in subclinical yet cancer-inducing inflammation that could be measurable in patient populations undergoing the therapy by examining cancer prevalence. An overall trend of increased incidence of new malignancy in patient populations on Infliximab compared with Adalimumab was confirmed from the literature reviewed. There was also a significant trend of developing Gastrointestinal (GI) related cancer in patients on Infliximab, which corresponds with the majority of the progression process in Crohn’s disease. It was opined that future observations in clinical practice will lead to the phasing out of Infliximab as a front-line monoclonal antibody in the treatment of Crohn’s disease in favor of less immunogenic monoclonal antibodies. In conclusion an increased incidence of both general and GI malignancies has been widely reported in patient populations undergoing Infliximab therapy than with Adalimumab.

Author(s) Details

Danil Hammoudi, MD
Department of Pathology, Saint James School of Medicine, BWI, Anguilla.

Adekunle Sanyaolu, PhD
Department of Medical Microbiology and Immunology, Saint James School of Medicine, BWI, Anguilla

Nirav Nagarsheth, MD, MBA
Department of Pathology, Saint James School of Medicine, BWI, Anguilla.

Jason Kimbel, M.D., MHA
Department of Pathology, Saint James School of Medicine, BWI, Anguilla.

Amos Abioye, PhD
Department of Pharmacy, Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, United Kingdom.

Read full article:
View Volume:


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s