Structure Assignment of the Two Isomers of 2-(1H-1,2,3-Triazol-1-yl)-Glycine N-Protected by Spectroscopic Methods and by Chemical Pathway| Chapter 4 | Theory and Applications of Chemistry Vol. 4

We describes in this chapter, the assignment of the 1,4- and 1,5-regioisomer structures of N-protected 2-(1H-1,2,3-triazol-1-yl)-glycine derivatives on the basis of 1H NMR, IR and chemical pathway. A subsequent assignment of 1,4- and 1,5-regioisomer structures of biheterocyclic glycine derivatives and their phosphonic analogues were based on spectroscopic study in 1H NMR and 13C NMR.

Author(s) Details :

Saïd Achamlale
Laboratory of Scientific Research and Pedagogic Development (LSRPD) CRMEF Fez-Meknes, Morocco.

Anouar Alami
Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Younas Aouine
Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.

Department of Chemistry, Faculty of Sciences, Ibn Zohr University, P.B. 8106, Cité Dakhla, Agadir 80060, Morocco

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Biological Studies of Newly Synthesized Benzo[d][1,2,3]triazole Derivatives | Chapter 06 | Theory and Applications of Chemistry Vol. 3

The study of heterocyclic systems provides most fascinating field for exploration in view of variety of interesting and intricate reactions, which lead to synthesis of unusual systems having diversities in their skeletal pattern. In this context, various new heterocycles and derivatives are synthesized with increased biological activities and less toxicity. Benzo-fused azoles containing three heteroatoms, specially, benzo[d][1,2,3]triazole, has received great attention, these days, for their chemical and biological properties and many of them are used as medicines for various diseases. Many researches have also shown that when heterocyclic and aliphatic secondary amines are introduced in a variety of heterocyclic compounds, the resulting compounds have been found to possess enhanced biological activities. Therefore aim of our research was to hook benzotriazole scaffold with these amines with a help of suitable linker in thirst of obtaining the resulting synthesized molecules possessing high and varied biological activities which can be useful to mankind in future. We have synthesized N-aminoalkylated derivatives of benzo[d][1,2,3]triazole. All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were evaluated for their antimicrobial activities in vitro.

Author(s) Details

Bharti Bhardwaj
Department of Chemistry, University of Delhi, Delhi-110 007, India.

Sunita Bhagat
Department of Chemistry, ARSD College, University of Delhi, India.

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