Buddleja Species Distributed in Mexico against Inflammatory Diseases, Their Therapeutic Activities, Secondary Metabolites and Biotechnology | Chapter 08 | Recent Advances in Biological Research Vol. 5

B. americana, B. cordata, B. parviflora, B. perfoliata, B. scordioides and B. sessiliflora, belonging to Buddleja Genus, are species distributed in Mexico reported in folk medicine to treat ills related to inflammatory processes. For some of them, this ethnopharmacological uses have been validated by scientific studies. Their phytochemistry has been related for their medicinal properties, being mainly iridoids, flavonoids and phenylethanoids because all of them are secondary metabolites credited with anti-inflammatory biological activity. Particularly, in folk medicine, those plants showing high concentrations of verbascoside secondary metabolite have been traditionally used to treat inflammation. In B. cordata, a cell culture has been developed since plant cell and tissue culture is a biotechnological tool that allows producing bioactive secondary metabolites in high concentrations as an alternative and sustainable form different to extraction from whole wild plants; meantime this protects wild medicinal plants from excessive use and collects. This cell culture produced verbascoside in a higher concentration than whole wild plant and the methanolic extract obtained from the cells demonstrated to be a satisfying anti-inflammatory agent on in vivo pre-clinical studies of acute and chronic inflammation, due to it modulates the production of interleukins expressed during an inflammatory process, lymphocytes tissue concentrations, decrease oxidative stress and leukocyte infiltration. New scientific studies should be done in those Buddleja species distributed in Mexico that have not credited its anti-inflammatory ethnomedicinal effect as well as to start on developing works to establish plant cell and tissue cultures. Moreover, new works should be continued about biotechnological advances on B. cordata. The aim of this work is to review the therapeutic activities, secondary metabolites and biotechnology advances of Buddleja species distributed in Mexico used against inflammatory diseases.

Author(s) Details

María Elena Estrada-Zúñiga
Centro de Investigación en Recursos Bióticos, Facultad de Ciencias, Universidad Autónoma del Estado de México, Carretera Toluca-Ixtlahuaca Km 14.5, San Cayetano CP 50295, Toluca, Estado de México, México.

Gabriel Alfonso Gutiérrez-Rebolledo
Departamento de Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco No. 186, Col. Vicentina CP 09340, México D.F., México.

Aurelio Nieto-Trujillo
Departamento de Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco No. 186, Col. Vicentina CP 09340, México D.F., México.

Dr. Antonio Bernabé-Antonio
Departamento de Madera, Celulosa y Papel, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Km. 15.5. Carretera Guadalajara-Nogales, Col. Las Agujas, CP 45010, Zapopan, Jalisco, México.

Francisco Cruz Sosa
Departamento de Biotecnología, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco No. 186, Col. Vicentina CP 09340, México D.F., México.

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Natural Compounds in the Treatment of Inflammatory lung Diseases: An Approach on Eucalyptol | Chapter 04 | Recent Advances in Biological Research Vol. 4

It is estimated that there will be an increase in the incidence of chronic obstructive pulmonary disease (COPD) in the coming decades. Thus, the pharmacological attributes of products of plant origin should be considered as an important economic and scientific strategy in the investigation of therapeutic alternatives, since their experimental validations are indispensable to substantiate the reliability of these products in the treatment of chronic diseases. Like biologically active compounds, Eucalyptol, also known as 1,8- cineole, is the major constituent of the leaf oil of eucalyptus species, such as Eucalyptus globulus and Eucalyptus tereticornis. It is a terpenoid oxide, free of steroid-like side effects. This study is based on a review of the specialised literature with purpose to discuss the biological effects of Eucalyptol in the respiratory system and its interaction with some of the most promising targets in the treatment of COPD, such as: receivers and membrane channels, oxidative stress, transcription and expression of cytokines, cell adhesion molecules and neutrophil chemotaxis, proteases and remodeling.

Author(s) Details

Fladimir de Lima Gondim
Postgraduate Program in Physiological Sciences, State University of Ceará, Ceará, Brazil.

Gilvan Ribeiro dos Santos
Center of Technological Sciences, State University of Ceará, Ceará, Brazil.

Daniel Silveira Serra
Center of Technological Sciences, State University of Ceará, Ceará, Brazil.

Francisco Sales Ávila Cavalcante
Center of Technological Sciences, State University of Ceará, Ceará, Brazil.

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A Review on Gongronema latifolium, an Extremely Useful Plant with Great Prospects | Chapter 11 | Recent Advances in Biological Research Vol. 3

Gongronema latifolium is a plant that has a wide range of nutritional and ethnomedical uses in different tropical African communities. Scientific reports on the chemical composition and bioactivity (anti-inflammatory, antimicrobial, antidiabetic, antioxidant, anticancer and allelopathic properties) of the plant material by different authors are discussed in this review. Future prospects of the plant extracts in the areas of herbal formulations, food preservation, alcoholic fermentation and beer production, drug discovery and allelopathy are also highlighted.

Author  Details:

Olugbenga Morebise

Faculty of Basic Medical Sciences, All Saints University School of Medicine, Roseau, Commonwealth of Dominica.

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