Prevalence of Urinary Tract Infection and Antibiotic Resistance Pattern in Pregnant Women, Najran Region, Saudi Arabia | Chapter 13 | Theory and Applications of Microbiology and Biotechnology Vol. 1

Urinary Tract Infection (UTI) is one of the commonest infectious disease in pregnancy, and in pregnancy we have very limited number of antibiotics to treat the UTI. This study was conducted on 151 patients who attended the gynecology clinic during the study period. Nineteen UTI proven cases of UTI were studied for prevalence of microorganism and sensitivity pattern against different antibiotics. Among the bacteria isolated, Escherichia coli (73.68%) and Staphylococcus aureus (10.52%) were the most prevalent Gram negative and Gram positive bacteria respectively. To know the resistance pattern of microorganism we used commercially available discs of different antibiotics. Gram negative bacteria showed more resistance as compared to Gram positive one. It is observed that the most effective antibiotic for Gram negative isolates is Ceftriaxone (87.5%), followed by Amoxicillin + Clavulanic acid (81.25%), Amikacin (75%), Cefuroxime (75%), Cefixime (68.75%) and Mezlocillin (62.5%). For the Gram positive bacteria, Ceftriaxone, Amikacin and Amoxicillin + Clavulanic acid were the most effective antimicrobials (100%). Multidrug resistance Gram negative bacteria were also tested for Extended-spectrum Beta Lactamase (ESBL), 35.71% of E. coli isolates were ESBL producer.

Author(s) Details

Dr. Ali Mohamed Alshabi
Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.

Dr. Majed Saeed Alshahrani
Department of Obstetics and Gyneocology, Faculty of Medicine, Najran University, Najran, Saudi Arabia.

Dr. Saad Ahmed Alkahtani
Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.

Mohammad Shabib Akhtar
Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.

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Nanoparticles as New Antimicrobial Agents | Book Publisher International

Antimicrobials are the synthetic molecules obtained from natural sources are widely used against pathogenic microbes. The improper use of these antimicrobial agents has resulted in multi-drug resistance property among various pathogens and is a great threat to the global population. Also, the spread of these resistant microbes is a great challenge to the medical practitioners. The use of novel technologies to replace conventional antimicrobials can curtain antimicrobial resistance. Nanotechnology driven innovations could give a hope for the patients as well as physicians in solving the problem of drug resistance. The medical and veterinary application of nanomaterials which are in the size of atomic or molecular scale has been tremendously increased. It has been well known that metallic compounds have high antimicrobial/bactericidal activity. Various nanomaterials have been documented against several bacteria. The development of an effective nanocomposite requires a profound knowledge on both physicochemical features of nanomaterials and biological characteristics of microbes. In addition, the health hazards linked to various nanoparticles need to be addressed thoroughly.

Author(s) Details

Dr. Mallappa Kumara Swamy (PhD)
Department of Biotechnology, East West First Grade College, Bengaluru, Karnataka, India.

Dr. Boregowda Purushotham
East West First Grade College, Bengaluru, India.

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