The Biological and Analytical Applications of Calixarenes Function: Facts and Growth Trends | Chapter 10 | Current Research and Development in Chemistry Vol.1

For over two decades, research on the biological and analytical applications of calixarenes and their derivatives has been shown remarkable properties towards organic and bioorganic molecules. Applications in the field of analytical chemistry and biological activity, as well as the anticancer properties of various calixarenes, have been studied and reported by several research groups. Due to their superior geometrical shape, calix[n]arenes structures (with n = 4; 6 or 8) have a special function, moreover, when combined with functional groups, the calixarenes can dissolve well and the low toxicity of the cell and the ability to form stable complexes with metal ion, especially the ability to transport drugs, it is allowed to be applied in the analysis and development of biosensors in fields: Biotechnology and drug discovery calixarene derivatives. The applications of calixarenes and their derivatives are summarized in this review, and future development prospects will be discussed.

Author(s) Details
Dr. Tran Quang Hieu
 Saigon Technology University, Ho Chi Minh City, Vietnam.

Dr. Nguyen Van Son
Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City, Vietnam

Dr. Tran Nguyen Minh An
Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City , Vietnam

Le Van Tan
Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City, Vietnam

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Prodrugs Design | Chapter 11 | Modern Advances in Pharmaceutical Research Vol. 2

Prodrug design can be used in the following cases: improving active drug solubility and consequently bioavailability, increasing permeability and absorption and modifying the drug’s distribution profile. In the prodrug design, a computational approach consisting of calculations using Molecular Orbital (MO) and Molecular Mechanics (MM) methods and correlations between experimental and calculated values can be utilized.

Author(s) Details

Professor Rafik Karaman
Department of Bioorganic Chemistry, Faculty of Pharmacy, Al-Quds University, P.O. Box 20002, Jerusalem, Palestine and Department of Sciences, University of Basilicata, Viadell’Ateneo Lucano 10, 85100, Potenza, Italy.

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The Future of Prodrugs Design | Chapter 03 | Modern Advances in Pharmaceutical Research Vol. 2

When knowledge fails to provide answers to important questions such as how to improve the bioavailability of vital medications, “Imagination is more important than knowledge,” as Albert Einstein once said. Ingenuity in the design of effective prodrugs has been lacking in quantity and quality. The reasons behind the low quality of ingenuity could be related to the fact that medicinal chemists have expertise in organic and organometalic chemistry not in biochemistry and biology. On the other hand, pharmaceutical chemists, biologists and biochemists do not have the expertise to make sophisticated chemical devices. Therefore, in order for a prodrug strategy to work, a team consisting of all this expertise is necessary.

Author(s) Details

Professor Rafik Karaman
Department of Bioorganic Chemistry, Faculty of Pharmacy, Al-Quds University, P.O. Box 20002, Jerusalem, Palestine and
Department of Sciences, University of Basilicata, Viadell’Ateneo Lucano 10, 85100, Potenza, Italy.

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