Evaluation of the Haemostatic Activities of Sida corymbosa in Rats | Chapter 02 | Modern Advances in Pharmaceutical Research Vol. 3

Aims: To evaluate the anti-haemorrhagic activity of the leaf extract of Sida corymbosa in Wistar albino rats, a plant used to arrest bleeding in ethnomedical practices.

Methods: The acute toxicity test was carried out in rats. The haemostatic activities of the extract were investigated using the tail bleeding time and amount of bleeding in rats; effects on haematological parameters were also evaluated in Wistar rats. Preliminary phytochemical analysis was conducted to detect the phytoconstituents of the extract of Sida corymbosa.

Results: In this study, the oral LD50 of the extract was found to be greater than 5 g/kg. Administration of the extract to rats for 14 days produced a dose-dependent and significant (P≤0.05) decrease in bleeding time and quantity of blood loss in pre-treated rats. On oral administration of the extract, the effects of the treatment on haematological parameters – White blood cells, Red blood cell, haemoglobin concentration were not significantly different from control.

Conclusion: This study has shown that Sida corymbosa has constituents with anti-haemorrhagic properties in rats thereby providing scientific validation for the ethnomedical use of the plant in bleeding control.

Author(s) Details

Lucy B. John-Africa
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Abuja, Nigeria.

Mercy Aboh
Department of Microbiology, Virology and Biotechnology National Institute for Pharmaceutical Research and Development, Idu Abuja, Nigeria.

View Volume: http://bp.bookpi.org/index.php/bpi/catalog/book/133