Phytochemicals and Acute Toxicity of Moringa oleifera Roots in Mice | Chapter 08 | Modern Advances in Pharmaceutical Research Vol. 3

The phytochemicals used by plants to protect themselves against predators in Moringa oleifera roots were qualitatively identified in the aqueous and ethanol extracts. Its acute toxicity in 24 h was evaluated in Swiss albino mice. M. oleifera, a native plant of the sub-Himalayan tracts of India, Pakistan, Bangladesh and Afghanistan is used in folk medicine. It is claimed to have nutritional, medicinal, socio-economic and industrial values. Many individuals and families consume the roots for their medicinal properties. Despite wide use the roots, the phytochemicals and toxicity profile are not well documented. This study set out to determine the phytochemicals and acute toxicity of M. oleifera roots in mice. The roots were harvested during dry season and air dried. Serial extractions using ether, ethanol and water were done. The harvested phytochemicals were qualitatively identified using standard chemicals procedures. The phytochemicals identified were: Gallic tannins, catechol tennins, steroids and triterponoids, saponins, anthraquinones, alkaloids, and reducing sugars. Acute toxicity was determined by giving a single oral dose to Swiss albino mice and observed for 24 h. The LD50 was calculated using the probit tables. The LD50 of ethanol extract was 17.8 g/kg and that of aqueous extract was 15.9 g/kg. In conclusion, M. oleifera roots contain protective phytochemicals and are relatively non-toxic when given in a single dose.

Author(s) Details

J. N. Kasolo
Department of Physiology, School of Biomedical Sciences, College of Health Sciences, Makererere University, P.O.Box 7072, Kampala, Uganda.

L. Ojok
Department of Pathology, Faculty of Veterinary Medicine, Makererere University, Kampala, Uganda.

W. Ogwal-Okeng
Department of Pharmacology and Therapeutics, School of Biomedical Sciences, College of Health Sciences, Makererere University, Kampala, Uganda.

G. S. Bimenya
Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makererere University, Kampala, Uganda.

View Volume: http://bp.bookpi.org/index.php/bpi/catalog/book/133

Natural Compounds in the Treatment of Inflammatory lung Diseases: An Approach on Eucalyptol | Chapter 04 | Recent Advances in Biological Research Vol. 4

It is estimated that there will be an increase in the incidence of chronic obstructive pulmonary disease (COPD) in the coming decades. Thus, the pharmacological attributes of products of plant origin should be considered as an important economic and scientific strategy in the investigation of therapeutic alternatives, since their experimental validations are indispensable to substantiate the reliability of these products in the treatment of chronic diseases. Like biologically active compounds, Eucalyptol, also known as 1,8- cineole, is the major constituent of the leaf oil of eucalyptus species, such as Eucalyptus globulus and Eucalyptus tereticornis. It is a terpenoid oxide, free of steroid-like side effects. This study is based on a review of the specialised literature with purpose to discuss the biological effects of Eucalyptol in the respiratory system and its interaction with some of the most promising targets in the treatment of COPD, such as: receivers and membrane channels, oxidative stress, transcription and expression of cytokines, cell adhesion molecules and neutrophil chemotaxis, proteases and remodeling.

Author(s) Details

Fladimir de Lima Gondim
Postgraduate Program in Physiological Sciences, State University of Ceará, Ceará, Brazil.

Gilvan Ribeiro dos Santos
Center of Technological Sciences, State University of Ceará, Ceará, Brazil.

Daniel Silveira Serra
Center of Technological Sciences, State University of Ceará, Ceará, Brazil.

Francisco Sales Ávila Cavalcante
Center of Technological Sciences, State University of Ceará, Ceará, Brazil.

Read full article: http://bp.bookpi.org/index.php/bpi/catalog/view/58/629/508-1
View Volume: https://doi.org/10.9734/bpi/rabr/v4