Ameliorating Effect of Moringa against Liver and Kidney Injury Induced by Monosodium Glutamate: Brief Overview | Chapter 9 | Current Research Trends in Biological Science Vol. 1

Background: Monosodium glutamate (MSG) produces adverse and damaging effects in different organs like liver and kidneys. Moringa has ameliorating effect on kidney and liver injury induced by monosodium glutamate.  Objective: To study the ameliorating effect of moringa against rats liver and kidney injury induced by monosodium glutamate. Design: Prospective study. Setting: College of Pharmacy, Qassim University. Materials and Methods: This study was performed on 20 male rats and equally divided into 4 groups. The first group was control group, second group was moringa group, third group was MSG group and forth group was MSG plus moringa group. We determined liver function, albumin, total protein, kidney function, electrolytes and histopathological examination of tissue. Main Outcome Results: Moringa has ameliorating effect on kidney and liver injury induced by monosodium glutamate. Sample Size:  A total of 20 malerats. Results: There was a significant increase in the levels of serum aspartate transaminase (AST) and alanine transaminase (ALT), alkaline phosphatase (ALP), urea and creatinine. Significant decrease in the levels of albumin, total proteins and sodium levels in rats treated with monosodium glutamate. Kidney sections revealed normal structure of glomeruli and renal tubules as control group, liver revealed good improvements and mild cellular infiltrations were observed in rats treated with MSG and moringa group. Conclusion: Moringa causes ameliorating effect on kidney and liver injury induced by monosodium glutamate in rats. Limitation of the Study: Few studies about the protective effect of Moringa against toxic effect of MSG.  So we need to focus on its beneficial effect against toxicity induced by MSG.

Author(s) Details

Dr. Rehab M. El-Gharabawy

Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Saudi Arabia and Department of Pharmacology and Toxicology, College of Pharmacy, Tanta University, Egypt.

Dr. Amira S. Ahmed
Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Saudi Arabia and Department of Hormones, National Research Centre, Egypt.

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Histo-Epidemiology of Kidney Cancer in Cameroon: About 110 Cases | Chapter 03 | New Insights into Disease and Pathogen Research Vol. 3

Objectives: To describe the epidemiological and histopathological aspects of kidney cancer in Cameroon.

Materials and Methods: This was a descriptive retrospective study on malignant tumors of the kidney examined in the anatomical pathology laboratories of five regions (Center, Littoral, West, South-west and North-west), over a period of 12 years (2004-2015). The studied parameters were: frequency, age, sex, histological type.

Results: A total of 110 cases of kidney cancer were collected, representing 8.55% of malignant urogenital tumors. The mean age of patients was 28.72±24.79 years (extremes: 4 months – 76 years). Females are relatively more affected than males (56 cases, 50.91%), with female-to-male ratio of 1.04:1. A total of 58 (52.73%) cases of renal cell carcinomas (RCC), 46 (41.82%) cases of nephroblastomas (NB) and 3 (2.73%) of soft tissue tumors were identified.

Conclusion: Kidney cancer is the third urogenital cancer in Cameroon characterized by a relative female predominance with renal cell carcinoma as the predominant histological type. Kidney cancer is the third urogenital cancer in Cameroon characterized by a relative female predominance with renal cell cancer as the predominant histological type. The fight against smoking, the prevention of diseases such as hypertension and diabetes are among the key elements that can help for the decrease in the prevalence of this pathology. It should be noted that the effective initiation of cancer registries is still essential to master the epidemiological data, foundation for a better coordination and prevention of the anti-cancer fight.

Author(s) Details

J. P. Ndamba Engbang
Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroon.
Laquintinie Hospital of Douala, Douala, Cameroon.
North-Ossetian State Medical Academy, Vladikavkaz, Russia.

B. Sala
Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroon.
Laquintinie Hospital of Douala, Douala, Cameroon.

C. Fonkwa
Laquintinie Hospital of Douala, Douala, Cameroon.

Y. Ligan
Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, Douala, Cameroon.

B. Djougmo Djimeli
Laquintinie Hospital of Douala, Douala, Cameroon.

G. Simo
Bio-Medical and Cancer Center of Bafoussam, Bafoussam, Cameroon.

A. Moune
Anapathos Laboratory, Douala, Cameroon.

A. Fewou
Douala General Hospital, Douala, Cameroon.

J. L. Oyono Essame
Faculty of Medicine and Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.
Yaounde University Health Center, Yaoundé, Cameroon.

A. Hasigov
North-Ossetian State Medical Academy, Vladikavkaz, Russia.

A. Ephiev
North-Ossetian State Medical Academy, Vladikavkaz, Russia.

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