Mechanisms of Prooxidants in Neuroinflammatory Processes and Clinical Manifestations | Chapter 07 | Current Trends in Medicine and Medical Research Vol. 5

In clinic practice the reduction of cerebral blood flow in particular zones of the brain as brainstem can cause early cerebral damage then, ischemia and posterior reperfusion induce an inflammatory response leading to further cellular death. Indeed, inflammatory cells may release deleterious compounds or cytokines that exacerbate oxidative damage to metabolically compromised neurons, and similar mechanisms may operate in the pathophysiology of neurodegenerative diseases in which vascular factors, inflammation and oxidative stress are implicated. In the present work, the issue referent to mechanisms of pro-oxidants in inflammatory processes and its relation with common pathogenesis and clinical manifestations are analyzed in detailed and updated form.

Author(s) Details

Calderón Guzmán David
Laboratory of Neurochemistry, Instituto Nacional de Pediatría (INP), Mexico.

Juárez Olguín Hugo
Laboratory of Pharmacology, Instituto Nacional de Pediatría (INP), Mexico.
Department of Pharmacology, School of Medicine, Universidad Nacional Autónoma de México, Mexico.

Hernández García Ernestina
Laboratory of Pharmacology, Instituto Nacional de Pediatría (INP), Mexico.

Osnaya Brizuela Norma
Laboratory of Neurochemistry, Instituto Nacional de Pediatría (INP), Mexico.

Saldivar González J. Alfredo
Department of Pharmacology, School of Medicine, Universidad Nacional Autónoma de México, Mexico.

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