Dental Treatment of a Child with Pallister-Killian Syndrome: Critical Research |Chapter 10 | Innovations in Medicine and Medical Research Vol.2

The Pallister-Killian syndrome (PKS) is an extremely rare genetic disorder with an incidence estimated around 1/25000 and a multiple congenital anomaly deficit syndrome caused by mosaic tissue limited tetrasomy for chromosome 12p. The presented report is the first confirmed case with PKS in Turkey. This report focuses on the orofacial clinical manifestations of an 6-year-old boy with PKS who was referred to the Department of Paediatric Dentistry clinic, Gazi University. It has been learned that the PKS was diagnosed 1 year after birth. Due to intellectual disability, it was decided to make the dental treatments under moderate sedation. Although significant tongue thrust and anterior open bite were determined, any oral appliances could not be applied because of the 2 epilepsy seizures in the last 2 years. The aim was to treat decayed teeth and set good oral hygiene in the patient’s mouth. Still, there is a probability for epilepsy seizures. If epileptic seizures stop permanently, we can apply an oral appliance to block tongue thrust. The patient is now under control. In cases of systemic and oral findings such as PKS, conducting medical and dental approaches together will increase the life quality of patients. Author(s) Details

Serhan Didinen
Department of Pediatric Dentistry, Faculty of Dentistry, Istanbul Medipol University, Turkey.

Didem Atabek
Department of Pediatric Dentistry, Faculty of Dentistry, Gazi University, Turkey.

Dr. Gülay Kip

Department of Pediatric Dentistry, Faculty of Dentistry, Gazi University, Turkey and Department of Anesthesia and Reanimation, Faculty of Medicine, Gazi University, Turkey

Asli Patir Münevveroglu
Department of Pediatric Dentistry, Faculty of Dentistry, Istanbul Medipol University, Turkey.

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Assessment of Antimalarial Drug Use among the Patients in a Tertiary Hospital in Northern Part of Nigeria | Chapter 05 | Current Trends in Disease and Health Vol. 1

Aims: To assess the pattern of antimalarial drug use among the patients attending the teaching hospital in Jos North local Government of Nigeria.

Study Design: Cross-sectional study.

Place and Duration of Study: Tertiary hospital in Jos North Local Government of Plateau state of Nigeria, between July and September, 2012.

Methodology: A sample size of 441 male and female patients was selected into this study using a universal sampling. Information on the knowledge, attitudes and practices with respect to antimalarial drug use were obtained with the aid of a pre-tested interviewer-administered questionnaire. Data was analyzed using the SPSS software.

Results: Four hundred and forty one (441) patients completed the questionnaire. Respondent knowledge of malaria with respect to description of malaria decreased (42.7% to 0.2%). Almost all the patients were able to describe the causes and symptoms of malaria. One hundred and sixty nine (38.3%) frequently treated their malaria with Sulphadoxine-Pyrimethamine (SP) combination, Three hundred and eighty two (86.6%) reported to have used oral preparation, almost half of the respondents (47.6%) obtained these medications from many sources apart from hospitals, only two hundred and forty eight reported to comply to treatment. Majority of the participants always used some methods for the prevention of malaria.

Conclusion: Concerted effort should be made to educate the population on malaria as well as the importance of drug adherence. Provision of ACTs at subsidized costs will go a long way in improving malaria treatment services in Nigeria, indigenous plantations for cultivating active ingredients and local manufacturing of ACTs is further expected to lower the costs of the drugs and increase its utilization and lower the incidence and impact of malaria. It will be important for interventions to be directed at educating the consumers on malaria pathogenesis, diagnosis, therapy and prevention and importance of drug adherence in order to improve the quality, efficacy of treatments and to reduce local morbidity and mortality in the future.

Author(s) Details

Modupe I. Builders
Department of Pharmacology, Faculty of Pharmacy, Bingham University, Karu, Nasarawa State, Nigeria.

Dr. Jonah Y. Peter
Department of Medical Microbiology and Parasitology, College of Health Sciences, University of Abuja, Abuja, Nigeria.

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