Plants remain an important source of new drugs, new drug leads for making more effective drugs in the pharmaceutical industry. Plant based discovery resulted mainly in the development of anticancer and anti-infective agents providing new leads to the drug industry.
The present article focuses on a unifying mode of action for the nutrients, namely, resveratrol, epigallocatechin, polyene-ß-carotene, polyene lycopene, piperine, curcumin, genistein, luteolin, sulforaphane and pomegranate extract. The mechanism is based on electron transfer, reactive oxygen species and oxidative stress, which comprises an extension of earlier reports involving agents. Most of the compounds are precursors of electron transfer quinones, whereas others fit into the polyene category. The nutrients are better known as antioxidants. The dichotomy is addressed.
Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182-1030, USA
Centro de Graduados e Investigación del Instituto Tecnológico de Tijuana, Mesa de Otay, Tijuana, B.C. Mexico.
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Ayurvedic textbooks ascribe many therapeutic properties such as anti-inflammatory, antimicrobial and antioxidant actions to Sida cordifolia Linn. which contains many polyphenols in its roots and seeds. Evaluation of in vivo antioxidant action in rats of the aqueous extract of Sida cordifolia Linn. roots has been done by introducing potassium dichromate for creating acute and chronic oxidative stress. The Folin- Ciocalteu reagent was utilized for assessing the phenol content which was determined as 27.375 mg Gallic acid/gm. During the acute toxicity tests using mice, no significant adverse signs or symptoms of toxicity were noticed up to the dose of 1500 mg/kg and no mortality was reported until this dosage. The Phosphomolybdate Assay using 3, 6 and 9 mg/ml of research drug concentrations resulted in determination of the Total Antioxidant Capacity that was found to be 15.40 ±9.13, 19.00 ±7.56 and 21.02 ±8.42 gm equivalents of Ascorbic acid. The results of the d-ROMs test which assessed the hydroperoxide levels clearly suggested that introduction of research drug could significantly counter the negative effects of both acute and chronic oxidative stress. Broadly similar findings were obtained by using ELISA kit for assessing ROS values where concurrent administration of the research drug resulted in very significant amelioration in respect of oxidative stress conditions.
Dr. Mradu Gupta
Institute of Post Graduate Ayurvedic Education and Research, 294/3/1, APC Road, Kolkata, India.
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