Therapeutic strategies using various preparations and their combinations with different mechanisms of action are gaining increasing attention. But the experiments are carried out in accordance with the work ethic on animals using anesthetics, which change the internal environment. We examined effect of urethane on rheological properties of erythrocytes in rats. Our results demonstrated negative effect resulting in worsens deformability and aggregability of the erythrocytes. Therefore studies on the effect of drugs to hematological parameters and blood rheology which were performed on urethane anesthetized animals, should be considered invalid and incorrect.
L. N. Katiukhin
Laboratory of Comparative Enzymes Biochemistry, Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg, Russia
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