Development on Tumor Associated Antigen with Specific Target toward Lung Cancer: Recent Developments | Chapter 19 | Innovations in Medicine and Medical Research Vol. 2

Tumor liberated protein (TLP) has been previously described as a TAA (complex) present in the sera from lung cancer patients with early stage disease. Since early detection improves overall survival in lung cancer, identification of screening biomarkers for patients at risk for the development of this disease represents an important target. Starting from the peptide epitope RTNKEASI previously isolated from TLP complexes, we generated a rabbit anti-RTNKEASI serum. This antiserum detected and immunoprecipitated a 55 kDa protein band in the lysate of the lung cancer cell line A549. This protein band was identified as aldehyde dehydrogenase is form 1A1 through mass spectrometry, revealing the molecular nature of at least one component of the previously described TLP complex. 

Author(s) Details

Giulio Tarro
Beaumont Bonelli Foundation for Cancer Research, Naples, Italy and Committee on Biotechnologies and VirusSphere, World Academy of Biomedical Technologies, UNESCO, Paris, France.

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Clinical Epidemiology of Chickenpox in Iraq, 2007-2011 | Chapter 04 | Innovations in Medicine and Medical Research Vol. 1

Chickenpox (Varicella zoster) infection is an acute disease caused by varicella zoster virus (VZV). In endemic areas, primary infection tends to occur at a younger age. The World Health Organization (WHO) recommended that routine childhood varicella vaccination should be considered in countries where the disease is a relatively important public health and socioeconomic problem, and where high (85 to 90%) and sustained vaccine coverage can be achieved.

Aim: 1- To describe the epidemiology (occurrence, age, gender and season) of registered clinical cases of chickenpox in Iraq from 2007-2011, 2- To determine the need for the use of chickenpox vaccine in Iraq.

Methods: A retrospective descriptive analysis of surveillance data. Frequency and percentage were used to describe the data. The occurrence per 100,000 of Iraqi population was calculated. Chi square test was used.

Results: There was an obvious rise in the registration of clinical chickenpox cases from 21,798 case in 2007 to 74, 195 case in 2011. This corresponds to an increase in the occurrence rate of clinical chickenpox cases from 73.41/100,000 in 2007 to 222.61/100, 000 in 2011. There were possible outbreaks in 2008 and 2011. The occurrence of chickenpox showed the same seasonal distribution throughout the years 2007-2011, being highest in spring (April, May) season. The highest registered number of chickenpox cases was in provinces of Ninawa, Baghdad/Russafa, Dihok, Baghdad/Karkh, Al-Basrah and As-Sulaymaniyah. There was a sustained preponderance for the males over females with nearly the same percentage over the years. Most of the cases occurred in those of age 5-14 years (65%), only 1% occur in those >45 years with statistical significance p=0.001.

Conclusions: There is a rising trend in the registration of clinical chickenpox cases. Most cases occur in the age group of less than 15 years. Males are slightly higher than females. The highest frequencies were reported in March, April and May. Most of the cases were registered in Baghdad, Ninawa, Dihok and Al-Basrah.

Author(s) Details

Hanan Abdulghafoor Khaleel
Viral Hepatitis Section, CDCC, Public Health Directorate, MOH, Iraq.

Dr. Hassan Muslem Abdulhussein
Public Health Directorate, MOH, Iraq.

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